Drug interactions in patients receiving purinethol mercaptopurine or imuran azathioprine , the concomitant administration of 300 to 600 mg of zyloprim per day will require a reduction in dose to approximately one third to one fourth of the usual dose of mercaptopurine or azathioprine.
Information about Zyloprim.
Take exactly as prescribed by your doctorDo not take in larger or smaller amounts or for longer than recommendedFollow the directions on your prescription label.
Experience with Zyloprim during human pregnancy has been limited partly because women of reproductive age rarely require treatment with ZyloprimThere are two unpublished reports and one published paper of women giving birth to normal offspring after receiving Zyloprim during pregnancy.
Teratogenic EffectsPregnancy Category CReproductive studies have been performed in rats and rabbits at doses up to twenty times the usual human dose5 mg/kg per dayand it was concluded that there was no impaired fertility or harm to the fetus due to allopurinolThere is a published report of a study in pregnant mice given 50 or 100 mg/kg allopurinol intraperitoneally on gestation days 10 or 13There were increased numbers of dead fetuses in dams given 100 mg/kg allopurinol but not in those given 50 mg/kgThere were increased numbers of external malformations in fetuses at both doses of allopurinol on gestation day 10 and increased numbers of skeletal malformations in fetuses at both doses on gestation day 13It cannot be determined whether this represented a fetal effect or an effect secondary to maternal toxicityThere arehoweverno adequate or well-controlled studies in pregnant womenBecause animal reproduction studies are not always predictive of human responsethis drug should be used during pregnancy only if clearly needed.
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