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Co-administration of nifedipine with grapefruit juice resulted in approximately a 2-fold increase in nifedipine AUC and Cmax with no change in half-lifeThe increased plasma concentrations are most likely due to inhibition of CYP 3A4 related first-pass metabolism.
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This is not a list of all drugs or health problems that interact with Procardianifedipine capsules
Mild to moderate peripheral edematypically associated with arterial vasodilation and not due to left ventricular dysfunctionoccurs in about one in ten patients treated with ProcardianifedipineThis edema occurs primarily in the lower extremities and usually responds to diuretic therapyWith patients whose angina is complicated by congestive heart failurecare should be taken to differentiate this peripheral edema from the effects of increasing left ventricular dysfunction.
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