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Methotrexate and other drugs thatlike LASIXundergo significant renal tubular secretion may reduce the effect of LASIXConverselyLASIX may decrease renal elimination of other drugs that undergo tubular secretionHigh-dose treatment of both LASIX and these other drugs may result in elevated serum levels of these drugs and may potentiate their toxicity as well as the toxicity of LASIX.
One study in six subjects demonstrated that the combination of furosemide and acetylsalicylic acid temporarily reduced creatinine clearance in patients with chronic renal insufficiencyThere are case reports of patients who developed increased BUNserum creatinine and serum potassium levelsand weight gain when furosemide was used in conjunction with NSAIDs.
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urine and blood glucose should be checked periodically in diabetics receiving lasix, even in those suspected of latent diabetes.