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Cyclophosphamide increases the occurrence of heart failure that is caused by doxorubicinAdriamycinincreases the action of blood thinners such as warfarinCoumadinand decreases the effectiveness of quinolone antibiotics ciprofloxacinCiproCipro XRProquin XR

CongenitalFamilial and Geneticintra-uterine deathfetal malformationfetal growth retardationfetal toxicityincluding myelosuppressiongastroenteritis

Amenorrhea associated with decreased estrogen and increased gonadotropin secretion develops in a significant proportion of women treated with cyclophosphamideAffected patients generally resume regular menses within a few months after cessation of therapyGirls treated with cyclophosphamide during prepubescence generally develop secondary sexual characteristics normally and have regular mensesOvarian fibrosis with apparently complete loss of germ cells after prolonged cyclophosphamide treatment in late prepubescence has been reportedGirls treated with cyclophosphamide during prepubescence subsequently have conceived.

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