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Usage of this drug during pregnancy should be avoided except in the suppression or treatment of malaria when in the judgment of the physician the benefit outweighs the possible hazardIt should be noted that radioactively-tagged chloroquine administered intravenously to pregnantpigmented CBA mice passed rapidly across the placentaIt accumulated selectively in the melanin structures of the fetal eyes and was retained in the ocular tissues for five months after the drug had been eliminated from the rest of the body.
In adultsfrom 400 mg to 600 mg310 mg to 465 mg basedailyeach dose to be taken with a meal or a glass of milkIn a small percentage of patientstroublesome side effects may require temporary reduction of the initial dosageLaterusually from five to ten daysthe dose may gradually be increased to the optimum response leveloften without return of side effects.
CRetinaMaculaEdemaatrophyabnormal pigmentationmild pigment stippling to abull’s-eyeappearanceloss of foveal reflexincreased macular recovery time following exposure to a bright lightphoto-stress testelevated retinal threshold to red light in macularparamacularand peripheral retinal areasCases of maculopathies and macular degeneration have been reported and may be irreversible.
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patients presenting with clinical symptoms suggestive of hypoglycemia during treatment with plaquenil should have their blood glucose checked and treatment reviewed as necessary.