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If you also use certain antibioticsheart rhythm medicationmigraine headache medicineanti-malaria medicationor medicine to treat depression or mental illness.
Drugs that affect the absorptiondistributionmetabolismand excretion of ketoconazole may alter the plasma concentrations of ketoconazoleFor examplegastric acid suppressantse.gantacidshistamine H2-blockersproton pump inhibitorshave been shown to reduce plasma concentrations of ketoconazole.
Pre-treatment with and concomitant administration of ketoconazole resulted in a 24-fold and 11-fold increase in mean AUC and Cmax of nisoldipinerespectivelycompared with treatment with nisoldipine 5 mg aloneConcomitant administration of ketoconazole with nisoldipine is contraindicatedSee CONTRAINDICATIONS section
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