Chloroquine may cause heart rhythm disorders in some patients caution should be taken when using chloroquine, if you were born with or have a family history of prolonged qt interval, if you have acquired qt prolongation seen on ecg, electrical recording of the heart , if you have heart disorders or have a history of heart attack myocardial infarction , if you have salt imbalance in the blood especially low level of potassium or magnesium, see section other medicines and your anti-malarial tablets .
Information about Chloroquine.
If there is any indicationpast or presentof abnormality in the visual acuityvisual fieldor retinal macular areassuch as pigmentary changesloss of foveal reflexor any visual symptomssuch as light flashes and streakswhich are not fully explainable by difficulties of accommodation or corneal opacitiesthe drug should be discontinued immediately and the patient closely observed for possible progressionRetinal changesand visual disturbancesmay progress even after cessation of therapy.
Because of the potential for serious adverse reactions in nursing infants from chloroquinea decision should be made whether to discontinue nursing or to discontinue the drugtaking into account the potential clinical benefit of the drug to the mother.
When prolonged therapy with any antimalarial compound is contemplatedinitialbase lineand periodic ophthalmologic examinationsincluding visual acuityexpert slit-lampfunduscopicand visual field testsshould be performed.
Keep all appointments with your doctor and the laboratoryYour doctor may order certain lab tests to check your response to chloroquine phosphateYour doctor will also test your reflexes to see if you have muscle weakness that may be caused by the drug.
If you also take an antibiotic called ampicillinPrincipenUnasynavoid taking it within 2 hours before or after you take chloroquineChloroquine can make ampicillin much less effective when taken at the same time.
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falciparum have become resistant to 4-aminoquinoline compounds including hydroxychloroquine as shown by the fact that normally adequate doses have failed to prevent or cure clinical malaria or parasitemia.