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In vitro protein binding studies have shown that bicalutamide can displace coumarin anticoagulants from binding sitesPT/INR should be closely monitored in patients concomitantly receiving coumarin anticoagulants and CasodexAdjustment of the anticoagulant dose may be necessarysee Warnings and Precautions5.2and Adverse Reactions6.2
Casodex 50 mg daily is indicated for use in combination therapy with a luteinizing hormone-releasing hormoneLHRHanalog for the treatment of Stage D 2 metastatic carcinoma of the prostate.
Bloating or swelling of the facearmshandslower legsor feet blood in the urine blurred vision body aches or pain chills congestion cough cough producing mucus difficult or labored breathing dizziness dryness or soreness of the throat fever headache hoarseness lower back or side pain nervousness painful or difficult urination pounding in the ears rapid weight gain runny nose slow or fast heartbeat sweating tenderswollen glands in the neck tightness in the chest tingling of the hands or feet trouble with swallowing unusual weight gain or loss voice changes.
Increased values in liver enzyme tests include increased ASTALTor bothThis effect has occurred in approximately 6of treated patientsRef]
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