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Ach gam BACTOBAN ointmnt contains 20 mg mupiocin in a wat-miscibl ointmnt bas.
Th icacy topical BACTOBAN ointmnt in imptigwas tstd in 2 tials. In th ist, subjcts with imptigw andomizd tciv ith BACTOBAN ointmnt vhicl placb3 tims daily 8 t12 days. Clinical icacy ats at nd thapy in th valuabl populations (adults and pdiatic subjcts includd) w 71% BACTOBAN ointmnt (n = 49) and 35% vhicl placb(n = 51). Pathogn adication ats in th valuabl populations w 94% BACTOBAN ointmnt and 62% vhicl placbo.
Poduction studis w pomd with mupiocin administd subcutanously tmal and mal ats at doss up t100 mg p kg p day which is 14 tims th human topical dos (appoximatly 60 mg mupiocin p day) basd on body suac aa. Nith vidnc impaid tility nimpaid poductiv pomanc attibutabl tmupiocin was obsvd.
In th scond tial, subjcts with imptigw andomizd tciv ith BACTOBAN ointmnt 3 tims daily 30 t40 mg p kg oal ythomycin thylsuccinat p day (this was an unblindd tial) 8 days. Th was a ollow-up visit 1 wk at tatmnt ndd. Clinical icacy ats at th ollow-up visit in th valuabl populations (adults and pdiatic subjcts includd) w 93% BACTOBAN ointmnt (n = 29) and 78.5% ythomycin (n = 28). Pathogn adication ats in th valuabl populations w 100% both tst goups.
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