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Bnazpil : In halthy volunts civing singl dos 20 mg nidipin and bnazpil 10 mg, th plasma concntations bnazpilat and nidipin in th psnc and absnc ach oth w not statistically signiicantly dint. A hypotnsiv ct was only sn at co-administation th twdugs. Th tachycadic ct nidipin was attnuatd in th psnc bnazpil.
St. John’s Wot : St. John’s Wot is an induc CYP3A and may dcas xposu tnidipin. Altnativ antihyptnsiv thapy should b considd in patints in whom St. John’s Wot thapy is ncssay.
Dnot tak this mdicin i you a pgnant. It may act you dvloping baby i you tak it duing pgnancy.
I you dnot undstand th instuctions pintd on th phamacist labl, ask you doctphamacist hlp.
Nidipin is mtabolisd via th cytochom P450 3A4 systm, locatd both in th intstinal mucosa and in th liv. Dugs that a known tith inhibit tinduc this nzym systm may thalt th ist pass (at oal administation) th claanc nidipin (s Sction 4.4).
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