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Distributed byValeant Pharmaceuticals North America LLC BridgewaterNJ 08807 USAMade in CanadaRevised11/14.
Administration of CARDIZEMdiltiazem hydrochlorideconcomitantly with propranolol in five normal volunteers resulted in increased propranolol levels in all subjectsand bioavailability of propranolol was increased approximately 50In vitropropranolol appears to be displaced from its binding sites by diltiazemIf combination therapy is initiated or withdrawn in conjunction with propranololan adjustment in the propranolol dose may be warrantedsee WARNINGS
Concomitant administration of diltiazem with carbamazepine has been reported to result in elevated serum levels of carbamazepine40to 72increaseresulting in toxicity in some casesPatients receiving these drugs concurrently should be monitored for a potential drug interaction.
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cardizem is absorbed from the tablet formulation to about 98 of a reference solution.