You should not take methotrexate if you have severe anemia, low white blood cell counts, or low platelet counts.
Information about Methotrexate.
DrRanganathan recommends taking 1 mg of folic acid dailythough for convenience some other physicians instruct patients to pop a single 5 mg dose once a weekSome doctors recommend taking folic acid 24 hours after receiving a dose of methotrexateask your physician for complete instructions on using folic acid supplements
This drug may make you dizzy or drowsyAlcohol or marijuana can make you more dizzy or drowsyDo not driveuse machineryor do anything that needs alertness until you can do it safelyAvoid alcoholic beveragesTalk to your doctor if you are using marijuana.
When methotrexate is less effectiveWhen methotrexate is used with certain drugsit may not work as well to treat your conditionThis is because the amount of methotrexate in your body may be decreasedExamples of these drugs include:
Examples of drugs that can cause interactions with methotrexate are listed below.
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more recent evidence suggests that high dose methotrexate may also overcome methotrexate resistance caused by impaired active transport, decreased affinity of dihydrofolic acid reductase for methotrexate, increased levels of dihydrofolic acid reductase resulting from gene amplification, or decreased polyglutamation of methotrexate.