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There are a few serious risks to considerLithium may weaken bones in childrenThe drug has also been linked to a specific birth defect in heart valve formation occurring in 1 in 1000 to 1 in 2000 patients and should be administered with caution to pregnant womenAlsoin a very few peoplelong-term lithium treatment can interfere with kidney function.
InfrequentAkathisiaapathyaphasiacentral nervous system depressiondepersonalizationdysarthriadyskinesiaeuphoriahallucinationshostilityhyperkinesiahypertonialibido decreasedmemory decreasemind racingmovement disordermyoclonuspanic attackparanoid reactionpersonality disorderpsychosissleep disorderstuporsuicidal ideation.
Patients in the control group were intentionally treated with a relatively low dose of valproateas suchthe sole objective of this trial was to demonstrate the effectiveness and safety of monotherapy with LAMICTALand cannot be interpreted to imply the superiority of LAMICTAL to an adequate dose of valproate.
In 339 patients aged 2 to 16 years with partial-onset seizures or generalized seizures of Lennox-Gastaut syndrome4.2of patients on LAMICTAL and 2.9of patients on placebo discontinued due to adverse reactionsThe most commonly reported adverse reaction that led to discontinuation of LAMICTAL was rash.
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