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A saturable and stereoselective neuronal binding site in rat brain tissue has been described for levetiracetamExperimental data indicate that this binding site is the synaptic vesicle protein SV2Athought to be involved in the regulation of vesicle exocytosisAlthough the molecular significance of levetiracetam binding to SV2A is not understoodlevetiracetam and related analogs showed a rank order of affinity for SV2A which correlated with the potency of their antiseizure activity in audiogenic seizure-prone miceThese findings suggest that the interaction of levetiracetam with the SV2A protein may contribute to the antiepileptic mechanism of action of the drug.
In manan activity in both partial and generalised epilepsy conditionsepileptiform discharge/photoparoxysmal responsehas confirmed the broad spectrum pharmacological profile of levetiracetam.
Somnolence and asthenia occurred most frequently within the first 4 weeks of treatmentIn generalthe incidences of somnolence and fatigue in the pediatric partial onset seizure studiesand in pediatric and adult myoclonic and primary generalized tonic-clonic seizure studies were comparable to those of the adult partial onset seizure studies.
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