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Estrogen therapy may cause an exacerbation of asthmadiabetes mellitusepilepsymigraineporphyriasystemic lupus erythematosusand hepatic hemangiomas and should be used with caution in women with these conditions.
In the WHI estrogen-alone substudya statistically significant increased risk of stroke was reported in women 50 to 79 years of age receiving daily CE0.625 mgalone compared to women in the same age group receiving placebo45 versus 33 per 10,000 women-yearsThe increase in risk was demonstrated in year 1 and persistedsee Clinical StudiesShould a stroke occur or be suspectedestrogen-alone therapy should be discontinued immediately.
This is not a complete list of side effects and others may occurCall your doctor for medical advice about side effectsYou may report side effects to FDA at 1-800-FDA-1088.
Estrogens may cause some degree of fluid retentionWomen with conditions that might be influenced by this factorsuch as cardiac or renal dysfunctionwarrant careful observation when estrogen-alone is prescribed.
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premarin is a mixture of estrogens indicated for .