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In larger dosesfludrocortisone acetate inhibits endogenous adrenal cortical secretionthymic activityand pituitary corticotropin excretionpromotes the deposition of liver glycogenandunless protein intake is adequateinduces negative nitrogen balance.
0.1 mg/day PO in combination with high salt diet and adequate fluid intakemay be increased in increments of 0.1 mg/wknot to exceed 1 mg/day.
Florinef Acetate TabletsFludrocortisone Acetate Tablets USP0.1 mg/tabletwhiteroundbiconvexscored tablets in bottles of 100NDC 61570-190-01identification no429.
Development of hypertensionedemahypokalemiaexcessive increase in weightand increase in heart size are signs of overdosage of fludrocortisone acetateWhen these are notedadministration of the drug should be discontinuedafter which the symptoms will usually subside within several dayssubsequent treatment with fludrocortisone acetate should be with a reduced doseMuscular weakness may develop due to excessive potassium loss and can be treated by administering a potassium supplementRegular monitoring of blood pressure and serum electrolytes can help to prevent overdosagesee WARNINGS
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