If you re going to get crestor on somebody s formulary, the issue will be how much in rebates astrazeneca is going to offer, says craig stern, pharm.

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Coadministration with other lipid-lowering therapyConsider dose reduction if combined with niacin or fenofibratebecause of increased risk for skeletal muscle effects.

Rosuvastatin crosses the placenta in rats and rabbits and is found in fetal tissue and amniotic fluid at 3and 20respectivelyof the maternal plasma concentration following a single 25 mg/kg oral gavage dose on gestation day 16 in ratsA higher fetal tissue distribution25maternal plasma concentrationwas observed in rabbits after a single oral gavage dose of 1 mg/kg on gestation day 18.

The U.SFood and Drug Administration approved Crestor in 2003 to lower cholesterol.

In a 12-week controlled study in boys and postmenarcheal girls 10 to 17 years of age with heterozygous familial hypercholesterolemia with CRESTOR 5 to 20 mg dailysee Use in Specific Populations and Clinical Studieselevations in serum creatine phosphokinaseCK10 x ULN were observed more frequently in rosuvastatin compared with placebo-treated childrenFour of 1303children treated with rosuvastatin2 treated with 10 mg and 2 treated with 20 mghad increased CK10 x ULNcompared to 0 of 46 children on placebo.

CRESTOR is indicated as an adjunct to diet for the treatment of adult patients with primary dysbetalipoproteinemiaType III Hyperlipoproteinemia

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