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The pharmacokinetics of theophylline vary widely among similar patients and cannot be predicted by agesexbody weight or other demographic characteristicsIn additioncertain concurrent illnesses and alterations in normal physiologysee Table Iand co-administration of other drugssee Table IIcan significantly alter the pharmacokinetic characteristics of theophyllineWithin-subject variability in metabolism has also been reported in some studiesespecially in acutely ill patientsIt isthereforerecommended that serum theophylline concentrations be measured frequently in acutely ill patientse.gat 24-hr intervalsand periodically in patients receiving long-term therapye.gat 6-12 month intervalsMore frequent measurements should be made in the presence of any condition that may significantly alter theophylline clearancesee PRECAUTIONSLaboratory Tests
It is very important that your doctor check the progress of you or your child at regular visitsespecially for the first few weeks after you begin using this medicineBlood tests may be needed to check for unwanted effects.
Stop using this medicine and check with your doctor right away if you or your child have the following symptoms while using this medicinenausea or vomiting that continuesheadachestrouble with sleepingseizuresor irregular heartbeats.
Do not stop or change the dose of this medicine without checking first with your doctor.
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