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The following adverse reactions have been identified during postapproval use of Protonix and Protonix I.VBecause these reactions are reported voluntarily from a population of uncertain sizeit is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure.
2Combine the contents of the two vials and further dilute with 80 mL of 5Dextrose InjectionUSP0.9Sodium Chloride InjectionUSPor Lactated Ringer’s InjectionUSPto a total volume of 100 mL with a final concentration of approximately 0.8 mg/mL.
Hepatobiliary Disordershepatocellular damage leading to jaundice and hepatic failure.
Very rareless than 0.01Hepatocellular failurecholestatic hepatitis/hepatitisjaundice.
Preparation and Administration Instructions for Pathological Hypersecretion Including Zollinger-Ellison Syndrome.
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in other words, powerful acid-suppressing drugs in the proton pump inhibitor category, such as esomeprazole nexium , lansoprazole prevacid , omeprazole prilosec , pantoprazole protonix and rabeprazole aciphex , were linked to an increased risk of heart attacks.