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This Medication Guide has been approved by the U.SFood and Drug Administration.
The dosage is based on your medical conditionother drugs/foods you may be takingand response to treatmentTo reduce your risk for serious side effectsdo not increase your dosetake it more frequentlyor take it for a longer time than directed by your doctorSerious side effects may occur even at usual prescribed doses.
Patients with both renal and hepatic impairment should not be given colchicine capsules.
Co-administration of colchicine capsules with propafenonea P-gp inhibitorat 225 mg BID for 5 daysin a pharmacokinetic study in healthy volunteersdid not cause any changes in systemic levels of colchicineThis indicates that propafenone can be administered with colchicine capsules without any dose adjustmentHoweverthese results should not be extrapolated to other P-gp inhibitors as colchicine is known to be a substrate for P-gp and case reports of colchicine toxicity associated with the co-administration of P-gp inhibitors such as cyclosporine have been published.
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cases of myopathy, including rhabdomyolysis, have been reported with atorvastatinco-administered with colchicine, and caution should be exercised when prescribing atorvastatin with colchicine see drug interactions .