Colchicine has other pharmacologic actions in animals it alters neuromuscular function, intensifies gastrointestinal activity by neurogenic stimulation, increases sensitivity to central depressants, heightens response to sympathomimetic compounds, depresses the respiratory center, constricts blood vessels, causes hypertension by central vasomotor stimulation, and lowers body temperature.
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do not eat grapefruit or drink grapefruit juice while you use colchicine.