In addition, because citalopram is a substrate for cyp2c19, the maximum daily dose of citalopram should not exceed 20 mg day in patients receiving cyp2c19 inhibitors such as efavirenz.
Information about Citalopram.
TABLE 3Treatment-Emergent Adverse EventsIncidence in Placebo-Controlled Clinical Trials
Tell your doctor if you’re taking these medicines before you start citalopram
Patients with major depressive disorderMDDboth adult and pediatricmay experience worsening of their depression and/or the emergence of suicidal ideation and behaviorsuicidalityor unusual changes in behaviorwhether or not they are taking antidepressant medicationsand this risk may persist until significant remission occursSuicide is a known risk of depression and certain other psychiatric disordersand these disorders themselves are the strongest predictors of suicideThere has been a long-standing concernhoweverthat antidepressants may have a role in inducing worsening of depression and the emergence of suicidality in certain patients during the early phases of treatment.
Because citalopram is extensively metabolizedexcretion of unchanged drug in urine is a minor route of eliminationUntil adequate numbers of patients with severe renal impairment have been evaluated during chronic treatment with Celexahoweverit should be used with caution in such patientssee DOSAGE AND ADMINISTRATION
If the decision has been made to discontinue treatmentmedication should be taperedas rapidly as is feasiblebut with recognition that abrupt discontinuation can be associated with certain symptomssee PRECAUTIONS and DOSAGE AND ADMINISTRATIONDiscontinuation of Treatment with Celexafor a description of the risks of discontinuation of Celexa
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some side effects of citalopram may occur that usually do not need medical attention.