Intensive clinical and laboratory monitoring, including liver enzyme tests, is essential at baseline and during the first 18 weeks of treatment with viramune.
Information about Viramune.
OsteonecrosisAlthough the etiology is considered to be multifactorialincluding corticosteroid usealcohol consumptionsevere immunosuppressionhigher body mass indexcases of osteonecrosis have been reported particularly in patients with advanced HIV-disease and/or long-term exposure to combination antiretroviral therapyCARTPatients should be advised to seek medical advice if they experience joint aches and painjoint stiffness or difficulty in movement.
The active substance in Viramunenevirapineis a non-nucleoside reverse-transcriptase inhibitorNNRTIIt blocks the activity of reverse transcriptasean enzyme produced by HIV-1 that allows it to infect cells in the body and make more virusesBy blocking this enzymeViramunetaken in combination with other antiviral medicinesreduces the amount of HIV-1 in the blood and keeps it at a low levelViramune does not cure HIV-1 infection or AIDSbut it may delay the damage to the immune system and the development of infections and diseases associated with AIDS.
Small studies of initial treatment have found that the combination of nevirapine with several dual-nucleoside analogue backbonesemtricitabinetenofovirdidanosinestavudineor lamivudinezidovudinecompares favorably with atazanavir/ritonavir5indinavir6or nelfinavir7plus the same nucleoside analoguesIn a small studythe combination of didanosinetenofovirnevirapine has demonstrated high rates of early virologic failure in treatment-naive individuals8It is not yet known why this regimen resulted in high failure ratespending further investigationthis combination should be avoided.
A dose increase for itraconazole should be considered when these two agents are administered concomitantly.
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if you are a woman with cd4 250 cells mm 3 or a man with cd4 400 cells mm 3 you should not begin taking viramune unless you and your doctor have decided that the benefit of doing so outweighs the risk.