I think people are trying to develop natural-product generics isolated from a different source than premarin , but it will be difficult.

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Premarin is also used as part of breast cancer treatment in both women and men.

The Women’s Health Initiative trialWHIfound no increase in the risk of breast cancer in hysterectomised women using estrogen-only HRTObservational studies have mostly reported a small increase in risk of having breast cancer diagnosed that is substantially lower than that found in users of estrogen-progestogen combinationssee section 4.8

The addition of a progestogen for at least 12 days per month/28 day cycle or continuous combined estrogen-progestogen therapy in non-hysterectomised women prevents the excess risk associated with estrogen-only HRT.

Premarin is sometimes taken on a daily basisFor certain conditionsthe medicine is given in a cyclesuch as 3 weeks on followed by 1 week offFollow your doctor’s instructions.

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