Eldepryl selegiline hydrochloride is a levorotatory acetylenic derivative of phenethylamine.
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MAO-B inhibition may be useful in this setting becauseby blocking the catabolism of dopamineit would increase the net amount of dopamine availablei.eit would increase the pool of dopamineWhether or not this mechanism or an alternative one actually accounts for the observed beneficial effects of adjunctive selegiline is unknown.
Take Eldepryl exactly as it was prescribed for youall directions on your prescription labelYour doctor may occasionally change your dose to make sure you get the best resultsDo not use this medicine in larger or smaller amounts or for longer than recommendedDo not change your doses or medication schedule without your doctor’s advice.
The chemical name isRN2-dimethylN2-propynylphenethylamine hydrochlorideIt is a white to near white crystalline powderfreely soluble in waterchloroformand methanoland has a molecular weight of 223.75The structural formula is as follows:
The combination of selegiline and oral contraceptives or drugs for hormone replacement therapyshould be avoidedas this combination may increase the bioavailability of selegiline.
The selectivity of selegiline for MAO-B may not be absolute even at the recommended daily dose of 10 mg a dayRare cases of hypertensive reactions associated with ingestion of tyramine-containing foods have been reported in patients taking the recommended daily dose of selegilineThe selectivity is further diminished with increasing daily dosesThe precise dose at which selegiline becomes a non-selective inhibitor of all MAO is unknownbut may be in the range of 30 to 40 mg a day.
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selegiline wikipedia, the free encyclopedia selegiline anipryl, l-deprenyl, eldepryl, emsam, zelapar is a drug used for the treatment of early-stage parkinson s disease, depression and dementia.