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Thiazides may reduce the renal excretion of cytotoxic medicinal productse.gcyclophosphamidemethotrexateand potentiate their myelosuppressive effectssee section 4.4
ACE-inhibitors and angiotensin II receptor blockers should not be used concomitantly in patients with diabetic nephropathy.
Breast-feeding Tell your doctor if you are breast-feeding or about to start breastfeedingZestoretic is not recommended for mothers who are breast-feedingand your doctor may choose another treatment for you if you wish to breast-feedespecially if your baby is newbornor was born prematurely.
Severe sweatingdiarrheaor vomiting can increase the risk for lightheadedness or a serious loss of body waterdehydrationReport prolonged diarrhea or vomiting to your doctorTo prevent dehydrationdrink plenty of fluids unless your doctor directs you otherwise.
In patients receiving thiazideshypersensitivity reactions may occur with or without a history of allergy or bronchial asthmaExacerbation or activation of systemic lupus erythematosus has been reported with the use of thiazides.
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