This last flare i m going through is more difficult so they gave me methotrexate and got so sick with the first dose i can t never take again.
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although methotrexate clearly ameliorates symptoms of inflammation pain, swelling, stiffness , there is no evidence that it induces remission of rheumatoid arthritis nor has a beneficial effect been demonstrated on bone erosions and other radiologic changes which result in impaired joint use, functional disability, and deformity.
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it has been postulated that the toxicity of methotrexate for normal tissues is more dependent upon the duration of exposure to the drug rather than the peak level achieved.
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serious adverse events were similar to the comparator dmards except severe weight loss and severe dermatological toxicity, which were higher in leflunomide and an increase in liver function tests lfts greater than three times the upper limit of normal, which was more common with methotrexate.
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salicylates severe caution should be exercised when salicylates are given in combination with methotrexate.
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in a small study methotrexate 5 10 mg week po was added to current sle treatment prednisone with or without cyclophosphamide .
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Some parents report that they asked for or were given the option to do the entire methotrexate iv treatment or at least the hydration part at home, with the child wearing a backpack for the iv containers.
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