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The three tetracycline antibioticstetracyclineoxytetracycline and chlortetracyclinewere the basis for obtaining new derivatives in order to obtain less toxic drugs with better therapeutic useSeveral byproducts were synthesized such as demeclocyclinerolitetracycline and the methacyclinewhich are considered first generation tetracyclinesAn inconvenient of these antibiotics was the short time they could persist in the bodyand it was overcome by the second generation tetracyclinedoxycycline and minocyclineSociedade Brasileira de Pediatria2012
KUMARKGUPTAS.CBAIDOOS.KCHANDLERYROSENC.JAntibiotic uptake by plants from soil fertilized with animal manureJEnvironQual.v.34p.2082-20852005Links
FMatthew KuhlmannJames MFleckensteinin Infectious DiseasesFourth Edition2017.
All tetracyclines have the same spectrum and mechanism of actionadverse effects and similar tolerances by resilient organismsHoweverthey present some differences regarding pharmacokineticsSociedade Brasileira de Pediatria2012
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the catabolic action of the tetracyclines may cause and increase in bun.