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The diurnal rhythm of the HPA axis is lost in Cushing’s diseasea syndrome of adrenocortical hyperfunction characterized by obesity with centripetal fat distributionthinning of the skin with easy bruisabilitymuscle wasting with weaknesshypertensionlatent diabetesosteoporosiselectrolyte imbalanceetcThe same clinical findings of hyperadrenocorticism may be noted during long-term pharmacologic dose corticoid therapy administered in conventional daily divided dosesIt would appearthenthat a disturbance in the diurnal cycle with maintenance of elevated corticoid values during the night may play a significant role in the development of undesirable corticoid effectsEscape from these constantly elevated plasma levels for even short periods of time may be instrumental in protecting against undesirable pharmacologic effects.
Some side effects may require medical attentionOther side effects do not require medical attention and may go away during treatmentPatients should check with their physician about any side effects that continue or are bothersome.
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How is this drug usedPrednisone is FDA approved for the treatment of leukemias and lymphomas in adults and acute leukemia of childhoodIt is also indicated for hypercalcemiahigh levels of calcium in the bloodassociated with cancer and mycosis fungoidesPrednisone may also be used to help prevent or reduce nausea and vomitingor to reduce the swelling surrounding cancerous tumors to relieve pressure caused by the swellingIt is important for patients to remember that physicians have the ability to prescribe medication for conditions other than those for which the drug has been approved by the FDAPatients who have received a prescription of this drug for a condition other than which it is approved may wish to discuss this issue with their physicianWhat is the mechanism of actionPrednisone belongs to a class of drugs called glucocorticoidsPrednisone produces its anti-cancer effects by inhibiting inflammatory agents in the bodywhich have been implicated in the development or growth of some cancers.
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