Subjects aged 36 to 76 years were randomized to bupropion 300 mg per day n 204 or placebo n 200 and treated for 12 weeks.
Information about Bupropion.
In short-term studiesantidepressants increased t suicidal thinking and behavior in childrenadolescentsand young adultsyounger than 24 yearstaking antidepressants for major depressive disorders and other psychiatric illnessesthis increase was not seen in patients older than 24 years Slight decrease in suicidal thinking was seen in adults older than 65 years In children and young adultsrisks must be weighed against the benefits of taking antidepressants Patients should be monitored closely for changes in behaviorclinical worseningand suicidal tendenciesthis should be done during initial 1-2 months of therapy and dosage adjustments The patient’s family should communicate any abrupt changes in behavior to the healthcare provider Worsening behavior and suicidal tendencies that are not part of the presenting symptoms may require discontinuation of therapythis drug is not approved for use in pediatric patients.
If you take Zyban to help you stop smokingyou may continue to smoke for about 1 week after you start the medicineSet a date to quit smoking during the second week of treatmentTalk to your doctor if you are having trouble quitting after you have used Zyban for at least 7 weeks.
Blurred visiontunnel visioneye pain or swellingor seeing halos around lights;
Risk of mydriasismay trigger angle closure attack in patients with angle closure glaucoma with anatomically narrow angles without a patent iridectomyuse caution.
InitialUp to 3 mg/kg/day or 150 mg/day orally Titrate to 6 mg/kg/day or 300 mg/daymaximum.
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older people clinical experience with bupropion has not identified any differences in tolerability between older and other adult patients.