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Claithomycin : Atovastatin AUC was signiicantly incasd with concomitant administation atovastatin 80 mg with claithomycin (500 mg twic daily) compad tthat atovastatin alon. Tho, in patints taking claithomycin, caution should b usd whn th dos atovastatin xcds 20 mg.
ATOLIP CV (atovastatin and clopidogl) is indicatd in patints whom tatmnt with both atovastatin and clopidogl is appopiat.
In adult patints without clinically vidnt CHD, but with multipl isk actos CHD such as ag, smoking, hyptnsion, low HDL-C, a amily histoy aly CHD, atovastatin is indicatd to.
Atovastatin is a slctiv, comptitiv inhibit3-hydoxy-3-mthylglutayl-conzym A (HMG-CoA) ductas, th at-limiting nzym that convts 3-HMG-CoA tmvalonat, a pcusstols, including cholstol. Cholstol and tiglycids (TG) ciculat in th bloodstam as pat lipopotin complxs. With ultacntiugation, ths complxs spaat inthigh-dnsity lipopotin (HDL), intmdiat-dnsity lipopotin (IDL), low-dnsity lipopotin (LDL) and vy-low-dnsity lipopotin (VLDL) actions. TG and cholstol in th liv a incopoatd intVLDL and lasd intth plasma dlivy tpiphal tissus. LDL is omd om VLDL and is catabolizd pimaily though th high-ainity LDL cpto.
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mild to moderate hemoglobin, hematocrit, and white blood cell decreases have been observed in patients following initiation of atorlip-f therapy.