With a median follow-up of 7 years, updated study results presented at ecco show five-year overall survival rates for xeloda at 71.
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Figure 4 Kaplan-Meier Estimates for Time to Disease Progression XELODA and Docetaxel vs Docetaxel.
Other than warfarinno formal drug-drug interaction studies between XELODA and other CYP2C9 substrates have been conductedCare should be exercised when XELODA is coadministered with CYP2C9 substrates.
Patients receiving concomitant capecitabine and oral coumarin-derivative anticoagulant therapy should have their anticoagulant responseINR or prothrombin timemonitored closely with great frequency and the anticoagulant dose should be adjusted accordinglysee BOX WARNING and DRUG INTERACTIONS
Diarrhea nausea vomiting mouth and throat sores loss of appetite or decreased appetite excessive water loss from the bodydehydrationhand-foot syndrome irregular periods this can include temporary cessationusually resume after medication is completedor permanent cessation of menstrual periods depending on your age and other factors.
In additionbetween 1 and 10 percent of the patients experience constipationheadachesand dizzinesseye problemshair loss or hair thinningabdominal painloss of appetitehigh levels of bilirubin in the bloodamenorrheaand loss of fertilitySide effects such as swollen ankles or chest pain happen in fewer than 1 percent of the patients.
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