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A patient who had taken lovastatin and pravastatin on different occasions developed reversible impotenceThe impotence resolved within 2 weeks after the HMG-CoA reductase inhibitor was discontinuedRef]

Frequency not reportedPositive ANAESR increasepolymyalgia rheumaticavasculitisRef]

In addition to eating a proper dietsuch as a low-cholesterol/low-fat dietother lifestyle changes that may help this medication work better include exercisinglosing weight if overweightand stopping smokingConsult your doctor for more details.

Frequency not reportedHepatitisincluding chronic active hepatitischolestatic jaundicefatty changes in the livercirrhosisfulminant hepatic necrosis Postmarketing reportsHepatic failureRef]

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All patients treated with vytorin should be advised to report promptly any symptoms that may indicate liver injury, including fatigue, anorexia, right upper abdominal discomfort, dark urine or jaundice.

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Vytorin is only part of a complete program of treatment that also includes dietexerciseand weight controlFollow your doctor’s instructions very closely.

Avoid drinking alcoholIt can raise triglyceride levels and may increase your risk of liver damage.

No incremental benefit of VYTORIN on cardiovascular morbidity and mortality over and above that demonstrated for simvastatin has been established.

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Other medicines may increase your risk of serious muscle problems if you take them together with VytorinDo not take these medicines at the same time:

Chinese Patients Taking Lipid-Modifying Dosesgreater than or equal to 1 g/day NiacinOf Niacin-Containing Products.

4Product InformationVytorinezetimibe-simvastatinMerckCompany IncWest PointPA.

Distributed byMerck SharpDohme Corpa subsidiary of MERCKCOINCWhitehouse StationNJ 08889USARevisedOct 2016.

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