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Strong inducers of cytochrome P450 enzymes and/or inducers of UGTe.grifampincarbamazepinephenytoin and phenobarbitalhave been shown to decrease the plasma/serum levels of MHDthe active metabolite of TRILEPTAL25to 49see CLINICAL PHARMACOLOGYIf TRILEPTAL and strong CYP3A4 inducers or UGT inducers are administered concurrentlyit is recommended that the plasma levels of MHD be monitored during the period of TRILEPTAL titrationDose adjustment of TRILEPTAL may be required after initiationdosage modificationor discontinuation of such inducers.

There is no specific antidoteSymptomatic and supportive treatment should be administered as appropriateRemoval of the drug by gastric lavage and/or inactivation by administering activated charcoal should be considered.

Skin and Subcutaneous Tissue Disorderserythema multiformeStevens-Johnson syndrometoxic epidermal necrolysissee WARNINGS AND PRECAUTIONSAcute Generalized Exanthematous PustulosisAGEP)

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Based on MHD concentrationsTRILEPTAL tablets and suspension were shown to have similar bioavailability.

TRILEPTAL is contraindicated in patients with a known hypersensitivity to oxcarbazepine or to any of its componentsor to eslicarbazepine acetatesee WARNINGS AND PRECAUTIONS

The half-life of the parent is about 2 hourswhile the half-life of MHD is about 9 hours.

Do not take TRILEPTAL if you are allergic to TRILEPTAL or any of the other ingredients in TRILEPTALor to eslicarbazepine acetateSee the end of this Medication Guide for a complete list of ingredients in TRILEPTAL.

Similar symptoms that are not related to low sodium may occur from taking TRILEPTALYou should tell your healthcare provider if you have any of these side effects and if they bother you or they do not go away.

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You think you may be allergic to carbamazepine or similar medicines like oxcarbazepine trileptal , to tricyclic antidepressants like amitriptyline, or to an epilepsy medicine called phenytoin you have any heart or liver problems you have ever had problems with your bone marrow you have a blood problem called porphyria you are from a han chinese or thai family background you have taken drugs called monoamine oxidase inhibitors maois , used to treat depression, within the last 14 days you are pregnant, or planning to become pregnant you are breastfeeding you have epilepsy where you get mixed types of fits seizures which include absences you have any eye problems such as glaucoma increased pressure in the eye .

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