The following agents, given together with triamterene, may promote serum potassium accumulation and possibly result in hyperkalemia because of the potassium-sparing nature of triamterene, especially in patients with renal insufficiency blood from blood bank may contain up to 30 meq of potassium per liter of plasma or up to 65 meq per liter of whole blood when stored for more than 10 days , low-salt milk may contain up to 60 meq of potassium per liter , potassium-containing medications such as parenteral penicillin g potassium , salt substitutes most contain substantial amounts of potassium .

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MAXZIDEtriamterene and hydrochlorothiazideshould not be used in the presence of elevated serum potassium levelsgreater than or equal to 5.5 mEq/literIf hyperkalemia developsthis drug should be discontinued and a thiazide alone should be substituted.

Abnormal elevation of serum potassium levelsgreater than or equal to 5.5 mEq/litercan occur with all potassium-conserving diuretic combinationsincluding MAXZIDEHyperkalemia is more likely to occur in patients with renal impairmentdiabeteseven without evidence of renal impairmentor elderly or severely ill patientsSince uncorrected hyperkalemia may be fatalserum potassium levels must be monitored at frequent intervals especially in patients first receiving MAXZIDEwhen dosages are changed or with any illness that may influence renal function.

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