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Because animal reproduction studies are not always predictive of human responsethis drug should be used during pregnancy only if clearly needed.

Hyperkalemia has been reported in diabetic patients with the use of potassium-conserving agents even in the absence of apparent renal impairmentAccordinglyMAXZIDEtriamterene and hydrochlorothiazideshould be avoided in diabetic patientsIf it is employedserum electrolytes must be frequently monitored.

Institute supportive measures as required to maintain hydrationelectrolyte balancerespiratorycardiovascular and renal function.

Triamterene is rapidly absorbed following oral administrationPeak plasma levels are achieved within one hour after dosingTriamterene is primarily metabolized to the sulfate conjugate of hydroxytriamtereneBoth the plasma and urine levels of this metabolite greatly exceed triamterene levels.

Institute supportive measures as required to maintain hydrationelectrolyte balancerespiratorycardiovascular and renal function.

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If you have diabetestriamterene may affect your blood sugarCheck your blood sugar regularly as directed and share the results with your doctorTell your doctor right away if you have symptoms of high blood sugar such as increased thirst/urinationYour doctor may need to adjust your diabetes medicationexercise programor diet.

Triamterene may be used alone or with other diureticseither for its added diuretic effect or its potassium-sparing potentialIt also promotes increased diuresis when patients prove resistant or only partially responsive to thiazides or other diuretics because of secondary hyperaldosteronism.

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thiazide diuretic and a potassium-sparing diuretic; used for htn and edema; triamterene counteracts potassium loss caused by hctz; efficacy is diminished in patients with renal insufficiency.

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Thiazides may add to or potentiate the action of other antihypertensive drugs.

Possible exacerbation or activation of systemic lupus erythematosus by thiazides has been reported.

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