The million dollar question is thus this since antibiotic only came into commercial use half a century ago how did tetracycline get into the kushitic bones.

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When exposed to the environmentantibiotics suffer oxidative degradationThe products resulting from oxidation of tetracyclines may be even more toxic than the parent compound against bacteria commonly found in the environmentBoxall2004KhetanCollins2007

Age at the time of administrationAnterior primary teeth are susceptible to discoloration by systemic tetracycline from 4 months in utero through 9 months postpartumAnterior permanent teeth are susceptible from 3 months postpartum through age 7 years91.

Inflammatory disorders take several weeks or months to respond to tetracyclines such as doxycyclineThey are often prescribed for months or years for inflammatory skin disordersThey are not curative for these conditions.

The original base medicineschlortetracyclinetetracycline and oxytetracyclinehave been replaced by products that are better absorbed and more lipophilicwith excellent tissue distributionThese include:

The main advantage of the antineoplasic action of tetracyclinesespecially doxycyclineis compared to greater tolerance with increasing dose of the drugallowing the synergistic treatment with drugs such as cisplatincurrently used in lower doseswhile maintaining the efficacy of the treatmentPereira-Maia et al 2010

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The three tetracycline antibioticstetracyclineoxytetracycline and chlortetracyclinewere the basis for obtaining new derivatives in order to obtain less toxic drugs with better therapeutic useSeveral byproducts were synthesized such as demeclocyclinerolitetracycline and the methacyclinewhich are considered first generation tetracyclinesAn inconvenient of these antibiotics was the short time they could persist in the bodyand it was overcome by the second generation tetracyclinedoxycycline and minocyclineSociedade Brasileira de Pediatria2012

KUMARKGUPTAS.CBAIDOOS.KCHANDLERYROSENC.JAntibiotic uptake by plants from soil fertilized with animal manureJEnvironQual.v.34p.2082-20852005Links

FMatthew KuhlmannJames MFleckensteinin Infectious DiseasesFourth Edition2017.

All tetracyclines have the same spectrum and mechanism of actionadverse effects and similar tolerances by resilient organismsHoweverthey present some differences regarding pharmacokineticsSociedade Brasileira de Pediatria2012

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Ribosome protection proteins rpps confer resistance to tetracycline by binding to the ribosome and chasing the drug from its binding site.

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