If tetracycline hydrochloride is used for the treatment of tularemia that occurs as the result of exposure to francisella tularensis in the context of biologic warfare or bioterrorism or naturally occurring or endemic tularemia, some experts recommend that adults receive 500 mg orally 4 times daily for at least 14-21 days.

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By Hans PSchlechtMDMScAssistant Professor of MedicineDepartment of MedicineDivision of Infectious DiseasesHIV MedicineDrexel University College of Medicine Christopher BrunoMDAssistant Professor of MedicineDivision of infectious DiseasesHIV MedicineDrexel University College of Medicine.

There is little evidence that tetracyclines reduce the efficacy of the oral contraceptive pill unless they cause gastrointestinal upsetHoweverto be absolutely safeextra precautions should be takenparticularly in the first four weeks of starting the antibioticsDiscuss this with your doctor.

Before taking tetracyclinetell your doctor if you are taking any of the following drugs:

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To reduce the development of drug-resistant bacteria and maintain the effectiveness of tetracycline hydrochloride and other antibacterial drugs, tetracycline hydrochloride should be used only to treat or prevent infections that are proven or strongly suspected to be caused by bacteria.

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Tetracyclines penetrate into most body tissues and fluidsAll are concentrated in unobstructed bileHoweverCSF levels are not reliably therapeuticMinocycline is the only tetracycline that reaches high concentrations in tears and saliva.

Many of them behave as weak acids or basisundergoing ionization in the pH conditions found in the environment;

FDA pregnancy category DThis medication can cause harm to an unborn babyincluding permanent discoloration of the teeth later in lifeDo not use tetracycline without your doctor’s consent if you are pregnantTell your doctor if you become pregnant during treatmentTetracycline can make birth control pills less effectiveUse a non-hormonal method of birth controlsuch as a condomdiaphragmspermicideto prevent pregnancy while you are taking tetracycline.

Every effort has been made to ensure that the information provided by Cerner MultumIncMultumis accurateup-to-dateand completebut no guarantee is made to that effectDrug information contained herein may be time sensitiveMultum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriateunless specifically indicated otherwiseMultum’s drug information does not endorse drugsdiagnose patients or recommend therapyMultum’s drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement toand not a substitute forthe expertiseskillknowledge and judgment of healthcare practitionersThe absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safeeffective or appropriate for any given patientMultum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum providesThe information contained herein is not intended to cover all possible usesdirectionsprecautionswarningsdrug interactionsallergic reactionsor adverse effectsIf you have questions about the drugs you are takingcheck with your doctornurse or pharmacist.

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Throw away any unused tetracycline when it expires or when it is no longer neededDo not take any tetracycline after the expiration date printed on the labelUsing expired tetracycline can cause damage to your kidneys.

All tetracyclines are about equally active and typically have about the same broad spectrumwhich comprises both aerobic and anaerobic gram-positive and gram-negative bacteriamycoplasmasrickettsiaechlamydiaeand even some protozoaamebaeTetracyclines generally are the drug of choice to treat rickettsiae and mycoplasmaAmong the susceptible organisms is Wolbachiaa rickettsial-like intracellular endosymbiont of nematodesincluding Dirofilaria immitisStrains of Pseudomonas aeruginosaProteusSerratiaKlebsiellaand Trueperella spp frequently are resistantas are many pathogenic Escherichia coli isolatesEven though there is general cross-resistance among tetracyclinesdoxycycline and minocycline usually are more effective against staphylococci.

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