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Partial seizures with complex symptomatologypsychomotortemporal lobePatients with these seizures appear to show greater improvement than those with other typesGeneralized tonic-clonic seizuresgrand malMixed seizure patterns which include the aboveor other partial or generalized seizuresAbsence seizurespetit maldo not appear to be controlled by Tegretolsee PRECAUTIONSGeneral

This Medication Guide summarizes the most important information about TEGRETOLIf you would like more informationtalk with your healthcare providerYou can ask your pharmacist or healthcare provider for the full prescribing information about TEGRETOL that is written for health professionals.

Carbamazepinewhen administered to Sprague-Dawley rats for two years in the diet at doses of 2575and 250 mg/kg/dayresulted in a dose-related increase in the incidence of hepatocellular tumors in females and of benign interstitial cell adenomas in the testes of males.

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Irregular heartbeatsymptoms includeFastslowor pounding heartbeat Shortness of breath Feeling lightheaded Fainting Liver problemssymptoms includeyellowing of your skin or the whites of your eyes dark urine pain on the right side of your stomach areaabdominal paineasy bruising loss of appetite nausea or vomiting.

APLASTIC ANEMIA AND AGRANULOCYTOSIS HAVE BEEN REPORTED IN ASSOCIATION WITH THE USE OF TEGRETOLDATA FROM A POPULATION-BASED CASE CONTROL STUDY DEMONSTRATE THAT THE RISK OF DEVELOPING THESE REACTIONS IS 5 TO 8 TIMES GREATER THAN IN THE GENERAL POPULATIONHOWEVERTHE OVERALL RISK OF THESE REACTIONS IN THE UNTREATED GENERAL POPULATION IS LOWAPPROXIMATELY SIX PATIENTS PER ONE MILLION POPULATION PER YEAR FOR AGRANULOCYTOSIS AND TWO PATIENTS PER ONE MILLION POPULATION PER YEAR FOR APLASTIC ANEMIA.

Call your healthcare provider right away if you have any of these symptomsespecially if they are newworseor worry you:

Carbamazepine mustthereforebe considered to be carcinogenic in Sprague-Dawley ratsBacterial and mammalian mutagenicity studies using carbamazepine produced negative resultsThe significance of these findings relative to the use of carbamazepine in humans isat presentunknown.

Dialysis is indicated only in severe poisoning associated with renal failureReplacement transfusion is indicated in severe poisoning in small children.

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