Sinemet is a combination of cardidopa and levodopa, used to treat parkinson s disease.

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Before initiating treatment with SINEMETadvise patients about the potential to develop drowsiness and ask specifically about factors that may increase the risk for somnolence with SINEMET such as the use of concomitant sedating medications and the presence of sleep disordersConsider discontinuing SINEMET in patients who report significant daytime sleepiness or episodes of falling asleep during activities that require active participatione.gconversationseatingetcIf treatment with SINEMET continuespatients should be advised not to drive and to avoid other potentially dangerous activities that might result in harm if the patients become somnolentThere is insufficient information to establish that dose reduction will eliminate episodes of falling asleep while engaged in activities of daily living.

For the reasons stated abovepatients and providers are advised to monitor for melanomas frequently and on a regular basis when using SINEMET for any indicationIdeallyperiodic skin examinations should be performed by appropriately qualified individualse.gdermatologists

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therapy with sinemet should be individualised and adjusted gradually according to response.

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There have been rare reports of adverse reactionsincluding hypertension and dyskinesiaresulting from the concomitant use of tricyclic antidepressants and SINEMET.

There have been reports of patients experiencing intense urges to gambleincreased sexual urgesand other intense urgesand the inability to control these urges while taking one or more of the medications that increase central dopaminergic tone and that are generally used for the treatment of Parkinson’s diseaseincluding SINEMETAlthough it is not proven that the medications caused these eventsthese urges were reported to have stopped in some cases when the dose was reduced or the medication was stoppedPrescribers should ask patients about the development of new or increased gambling urgessexual urges or other urges while being treated with SINEMETPatients should inform their physician if they experience new or increased gambling urgesincreased sexual urgesor other intense urges while taking SINEMETPhysicians should consider dose reduction or stopping the medication if a patient develops such urges while taking SINEMETSee PRECAUTIONSImpulse ControlCompulsive Behaviors

SINEMET helps control some of your symptoms of Parkinson’s diseasebut does not cure itTherefore SINEMET must be taken every dayContinue taking SINEMET for as long as your doctor prescribes.

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