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How to take Take your dose of Reminyl twice a dayin the morning and eveningwith water or other liquidsTry to take Reminyl with foodDrink plenty of liquids while you are taking Reminylto keep yourself hydrated.

An increase to the maintenance dose of 24 mg/day12 mg twice a dayshould be considered on an individual basis after appropriate assessment including evaluation of clinical benefit and tolerability.

Therapeutic doses of galantamine 24 mg/day had no effect on the kinetics of digoxinalthough pharmacodynamic interactions may occursee also pharmacodynamic interactions

The use of galantamine is contraindicated in patients with creatinine clearance less than 9 ml/minsee section 4.3

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Serious skin reactionsStevens-Johnson syndrome and acute generalized exanthematous pustulosishave been reported in patients receiving Reminylsee section 4.8It is recommended that patients be informed about the signs of serious skin reactionsand that use of Reminyl be discontinued at the first appearance of skin rash.

In a pooled analysis of placebo-controlled studies in patients with Alzheimer’s dementia treated with galantamine an increased incidence of certain cardiovascular adverse events were observedsee section 4.8

Your healthcare professionalse.gdoctor or pharmacistmay already be aware of any possible drug interactions and may be monitoring you for itDo not startstop or change the dosage of any medicine before checking with them first.

The table below reflects data obtained with Reminyl in eight placebo-controlleddouble-blind clinical trialsN=6,502five open-label clinical trialsN=1,454and from postmarketing spontaneous reportsThe most commonly reported adverse reactions were nausea21and vomiting11They occurred mainly during titration periodslasted less than a week in most cases and the majority of patients had one episodePrescription of anti-emetics and ensuring adequate fluid intake may be useful in these instances.

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