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Safety and effectiveness in pediatric patients have not been established except as stated to facilitate small bowel intubationsee OVERDOSAGE and DOSAGE AND ADMINISTRATION

Safety and effectiveness in pediatric patients have not been establishedsee OVERDOSE

Tell your doctor right away if you develop any unusual uncontrolled movementsespecially of the facemouthtonguearms or legsThere is no treatment for tardive dyskinesiabut in some cases the symptoms may lessen or stop once metoclopramide is stopped.

Metoclopramide increases the tone and amplitude of gastricespecially antralcontractionsrelaxes the pyloric sphincter and the duodenal bulband increases peristalsis of the duodenum and jejunum resulting in accelerated gastric emptying and intestinal transitIt increases the resting tone of the lower esophageal sphincterIt has littleif anyeffect on the motility of the colon or gallbladder.

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Unintentional overdose due to misadministration has been reported in infants and children with the use of Reglan syrupWhile there was no consistent pattern to the reports associated with these overdosesevents included seizuresextrapyramidal reactionsand lethargy.

There are insufficient reliable data to conclude whether the pharmacokinetics of metoclopramide in adults and the pediatric population are similarAlthough there are insufficient data to support the efficacy of metoclopramide in pediatric patients with symptomatic gastroesophageal refluxGERor cancer chemotherapy-related nausea and vomitingits pharmacokinetics have been studied in these patient populations.

Giving a promotility drug such as metoclopramide theoretically could put increased pressure on suture lines following a gut anastomosis or closureThis possibility should be considered and weighed when deciding whether to use metoclopramide or nasogastric suction in the prevention of postoperative nausea and vomiting.

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