In adults, symptomatic response to therapy with protonix does not preclude the presence of gastric malignancy.

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Taste pervasion most frequently occurred in patients given triple therapybut it was also very common in patients given quadruple therapyRef]

In clinical studies of ZE Syndromeadverse reactions reported in 35 patients administered Protonix I.Vdoses of 80 mg to 240 mg per day for up to 2 years were similar to those reported in adult patients with GERD.

Take this medication by mouth as directed by your doctorusually once dailyDosage and length of treatment are based on your medical condition and response to treatment.

Rarelyproton pump inhibitorssuch as pantoprazolehave caused vitamin B-12 deficiencyThe risk is increased if they are taken every day for a long time3 years or longerTell your doctor right away if you develop symptoms of vitamin B-12 deficiencysuch as unusual weaknesssore tongueor numbness/tingling of the hands/feet

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Protonix is classified as a category b drug, which is not tested on pregnant ladies.

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Table 2 includes drugs with clinically important drug interactions and interaction with diagnostics when administered concomitantly with Protonix I.Vand instructions for preventing or managing them.

The following serious adverse reactions are described below and elsewhere in labeling:

A very serious allergic reaction to this drug is rareHoweverget medical help right away if you notice any symptoms of a serious allergic reactionincludingrashitching/swellingespecially of the face/tongue/throatsevere dizzinesstrouble breathingsigns of kidney problemssuch as change in the amount of urine

Tell your doctor if your condition persists or worsensThe risk of side effects goes up over timeAsk your doctor how long you should take this medication.

Pantoprazole is extensively metabolized in the liver through the cytochrome P450CYPsystemPantoprazole metabolism is independent of the route of administrationintravenous or oralThe main metabolic pathway is demethylationby CYP2C19with subsequent sulfationother metabolic pathways include oxidation by CYP3A4There is no evidence that any of the pantoprazole metabolites have significant pharmacologic activityCYP2C19 displays a known genetic polymorphism due to its deficiency in some sub-populationse.g3of Caucasians and African-Americans and 17 to 23of AsiansAlthough these sub-populations of slow pantoprazole metabolizers have elimination half-life values from 3.5 to 10 hoursthey still have minimal accumulation23or lesswith once daily dosing.

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