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The ratio of free to total PSApercent free PSAremains constant even under the influence of PROSCARIf clinicians elect to use percent free PSA as an aid in the detection of prostate cancer in men undergoing finasteride therapyno adjustment to its value appears necessary.
Using Proscar may increase your risk of developing prostate cancerYour doctor will perform tests to make sure you do not have other conditions that would prevent you from safely using finasteride.
In sexually mature male rabbits treated with finasteride at 543 times the human exposure80 mg/kg/dayfor up to 12 weeksno effect on fertilitysperm countor ejaculate volume was seenIn sexually mature male rats treated with 61 times the human exposure80 mg/kg/daythere were no significant effects on fertility after 6 or 12 weeks of treatmenthoweverwhen treatment was continued for up to 24 or 30 weeksthere was an apparent decrease in fertilityfecundity and an associated significant decrease in the weights of the seminal vesicles and prostateAll these effects were reversible within 6 weeks of discontinuation of treatmentNo drug-related effect on testes or on mating performance has been seen in rats or rabbitsThis decrease in fertility in finasteride-treated rats is secondary to its effect on accessory sex organsprostate and seminal vesiclesresulting in failure to form a seminal plugThe seminal plug is essential for normal fertility in rats and is not relevant in man.
Keep all appointments with your doctor and the laboratoryYou should have a complete physical examinationFollow your doctor’s instructions for examining your breasts and testiclesand report any lumps right away.
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although specific interaction studies were not performed, proscar was concomitantly used in clinical studies with acetaminophen, acetylsalicylic acid, -blockers, angiotensin-converting enzyme ace inhibitors, analgesics, anti-convulsants, beta-adrenergic blocking agents, diuretics, calcium channel blockers, cardiac nitrates, hmg-coa reductase inhibitors, nonsteroidal anti-inflammatory drugs nsaids , benzodiazepines, h 2 antagonists and quinolone anti-infectives without evidence of clinically significant adverse interactions.
