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Calcium-channel blocking agents may increase tacrolimus blood concentrations and therefore require dosage reduction of prograf see drug interactions .

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Tacrolimus can make you more likely to get infections or may worsen any current infectionsThereforewash your hands well to prevent the spread of infectionAvoid contact with people who have infections that may spread to otherssuch as chickenpoxmeaslesfluConsult your doctor if you have been exposed to an infection or for more details.

The risk of QT prolongation may be increased if you have certain medical conditions or are taking other drugs that may cause QT prolongationBefore using tacrolimustell your doctor or pharmacist of all the drugs you take and if you have any of the following conditionscertain heart problemsheart failureslow heartbeatQT prolongation in the EKGfamily history of certain heart problemsQT prolongation in the EKGsudden cardiac death

This medication may also increase your risk of getting a rare but very serioussometimes fatalbrain infectionprogressive multifocal leukoencephalopathy-PMLGet medical help right away if any of these rare but very serious side effects occurclumsinessloss of coordinationweaknesssudden change in your thinkingsuch as confusiondifficulty concentratingdifficulty moving your musclesproblems with speechseizurevision changes.

Some people taking Prograf after a kidney transplant have developed diabetesThis effect has been seen most commonly in people who are Hispanic or African-AmericanTalk with your doctor about your individual risk of diabetes if you have concerns.

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It is possible in some cases to withdraw concomitant immunosuppressive therapy, leading to prograf-based dual-therapy.

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Children who have trouble swallowing capsules can be given PROGRAF GranulesGive the dose of PROGRAF Granules right after preparingDo not save prepared PROGRAF Granules as a liquid to take at a later timeSee the Instructions for Use at the end of the Patient Information for detailed instructions about how to mix and give PROGRAF Granules as a liquidIf you get the granulesor prepared oral suspension on your skinwash the area well with soap and waterIf you get the granulesor prepared oral suspension in your eyesrinse with plain water.

Prograf should not be used simultaneously with cyclosporinesee DOSAGE AND ADMINISTRATION

Table 1Summary of Initial Oral Dosage Recommendations and Observed Whole Blood Trough Concentrations in Adults.

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You will need regular medical tests to be sure Prograf is not causing harmful effectsDo not miss any follow up visits to your doctor for blood or urine testsAvoid being near people who are sick or have infections.

The data in kidney transplant patients indicate that the Black patients required a higher dose to attain comparable trough concentrations compared to Caucasian patientsTable 2

ISMP Canada gratefully acknowledges the expert review of this article byin alphabetical orderPatti CornishRPhBScPhmPatient Safety ServiceSunnybrook Health Sciences CentreJennifer HarrisonBScPhmMScPharmacy Clinical Site LeaderUniversity Health NetworkNicola RosaasenBScBSPPharmacistSaskatchewan Transplant ProgramJeffrey SchiffMDFRCPCMulti-Organ Transplant ProgramToronto General HospitalJohn W SendersPhDProfessor EmeritusUniversity of TorontoAnita WongBScPharmRexall Outpatient PharmacyUniversity of Alberta Hospitaland Ken WouBSc(Pharmpharmacy consultant.

Medication incidentsincluding near missescan be reported to ISMP Canada in 1 of 2 ways:

Inactive ingredientsPROGRAF capsulescroscarmellose sodiumhypromelloselactose monohydrateand magnesium stearateThe 0.5 mg capsule shell contains ferric oxidegelatinand titanium dioxideThe 1 mg capsule shell contains gelatin and titanium dioxideThe 5 mg capsule shell contains ferric oxidegelatinand titanium dioxidePROGRAF Granulescroscarmellose sodiumhypromelloseand lactose monohydrate.

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