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There were no patients on prandin-thiazolidinedione combination therapy who had elevations of liver transaminases defined as 3 times the upper limit of normal levels .

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The safety of using Prandin in pregnancy has not been establishedWomen using Prandin who are pregnant or contemplating pregnancy should tell their healthcare provider immediately so the right medication can be prescribedPeople with type 1 diabetesSome people with kidney or liver disease may need a dose adjustment.

Most medications interact safely with PrandinSome antifungal medications and antibiotics howevermay effect the action of PrandinAlways remind your healthcare provider what medicines you are taking and when there is a change in your medicationsThis will help ensure the combinations are safeWhen started on a new medicationask your healthcare provider if the new medication will affect your diabetes.

Take within 30 minutes before mealsskip dose if meal is skippedadd dose if meal is addedTreatment-naiveor HbA1c.

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Beta-blocker medicationssuch as metoprololpropranololglaucoma eye drops such as timololmay prevent the fast/pounding heartbeat you would usually feel when your blood sugar falls too lowhypoglycemiaOther symptoms of low blood sugar such as dizzinesshungeror sweating are unaffected by these drugs.

Adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.

The dosage should be determined by the physicianaccording to the patient’s requirements.

Rifampicina potent inducer of CYP3A4but also CYP2C8acts both as an inducer and inhibitor of the metabolism of repaglinideSeven days pre-treatment with rifampicin600 mgfollowed by co-administration of repaglinidea single dose of 4 mgat day seven resulted in a 50lower AUCeffect of a combined induction and inhibitionWhen repaglinide was given 24 hours after the last rifampicin dosean 80reduction of the repaglinide AUC was observedeffect of induction aloneConcomitant use of rifampicin and repaglinide might therefore induce a need for repaglinide dose adjustment which should be based on carefully monitored blood glucose concentrations at both initiation of rifampicin treatmentacute inhibitionfollowing dosingmixed inhibition and inductionwithdrawalinduction aloneand up to approximately two weeks after withdrawal of rifampicin where the inductive effect of rifampicin is no longer presentIt cannot be excluded that other inducerse.gphenytoincarbamazepinephenobarbitalSt John’s wortmay have a similar effect.

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