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Advise patients to be alert for the symptoms of cardiovascular thrombotic eventsincluding chest painshortness of breathweaknessor slurring of speechand to report any of these symptoms to their healthcare provider immediatelysee WARNINGSCardiovascular Thrombotic Events

This is not a complete list of side effects and others may occurCall your doctor for medical advice about side effectsYou may report side effects to FDA at 1-800-FDA-1088.

Advise the patient to read the FDA-approved patient labelingMedication Guidethat accompanies each prescription dispensedInform patientsfamilies and their caregivers of the following information before initiating therapy with Ponstel and periodically during the course of ongoing therapy.

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we currently use the services of seven third-party manufacturers for our products and have entered into an agreement with one which is scheduled to begin the manufacture of ponstel for us during the fourth quarter of 2001 after obtaining fda approval to do so.

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Kidney problems can sometimes occur with the use of NSAID medicationsincluding mefenamic acidProblems are more likely to occur if you are dehydratedhave heart failure or kidney diseaseare an older adultor if you take certain medicationssee also Drug Interactions sectionDrink plenty of fluids as directed by your doctor to prevent dehydration and tell your doctor right away if you have a change in the amount of urine.

This medication should not be used if you have certain medical conditionsBefore using this medicineconsult your doctor or pharmacist if you haveaspirin-sensitive asthmaa history of worsening breathing with runny/stuffy nose after taking aspirin or other NSAIDssevere kidney diseaserecent heart bypass surgeryCABGactive bleeding/sores in stomach/intestinesulcergastrointestinal bleeding

Advise patients to report symptoms of ulcerations and bleedingincluding epigastric paindyspepsiamelenaand hematemesis to their healthcare providerIn the setting of concomitant use of low-dose aspirin for cardiac prophylaxisinform patients of the increased risk for and the signs and symptoms of GI bleedingsee WARNINGSGastrointestinal BleedingUlcerationand Perforation

This medicine can increase your risk of life-threatening heart or circulation problemsincluding heart attack or strokeDo not use this medicine just before or after having heart bypass surgeryalso called coronary artery bypass graftor CABG

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