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Caution is needed when co-administering cilostazol with any other agent which has the potential to reduce blood pressure due to the possibility that there may be an additive hypotensive effect with a reflex tachycardia.

Patients may respond as early as 2 to 4 weeks after the initiation of therapybut treatment for up to 12 weeks may be needed before a beneficial effect is experiencedIf symptoms are unimproved after 3 monthsdiscontinue PLETAL.

Pletal and several of its metabolites inhibit phosphodiesterase III activity and suppress cAMP degradation with a resultant increase in cAMP in platelets and blood vesselsleading to inhibition of platelet aggregation and vasodilationrespectively.

It is unknown if this medication passes into breast milkConsult your doctor before breast-feeding.

This drug may make you dizzyAlcohol or marijuana can make you more dizzyDo not driveuse machineryor do anything that needs alertness until you can do it safelyLimit alcoholic beveragesTalk to your doctor if you are using marijuana.

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To lower the chance of getting cutbruisedor injureduse caution with sharp objects like razors and nail cuttersand avoid activities such as contact sports.

Medications similar to cilostazol have caused seriouspossibly fatalproblems in people with a certain type of heart diseaseheart failureThereforedo not use cilostazol if you have heart failure.

We comply with the HONcode standard for trustworthy health informationverify here.

No dose adjustment is required in patients with mild hepatic impairmentPatients with moderate or severe hepatic impairment have not been studied in clinical trials and dosing recommendations cannot be providedsee Clinical Pharmacology12.3

Cardiovascularatrial fibrillationheart failuremyocardial infarctionnodal arrhythmiasupraventricular tachycardiaventricular extrasystolesventricular tachycardia.

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Improvement in symptoms may occur as soon as 2 weeksbut could take up to 12 weeks.

Because clinical trials are conducted under widely varying conditionsadverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice.

Dietary administration of cilostazol to male and female rats and mice for up to 104 weeksat doses up to 500 mg/kg/day in rats and 1000 mg/kg/day in micerevealed no evidence of carcinogenic potentialThe maximum doses administered in both rat and mouse studies wereon a systemic exposure basisless than the human exposure at the MRHD of the drugCilostazol tested negative in bacterial gene mutationbacterial DNA repairmammalian cell gene mutationand mouse in vivo bone marrow chromosomal aberration assaysIt washoweverassociated with a significant increase in chromosomal aberrations in the in vitro Chinese Hamster Ovary Cell assay.

Read the Patient Information Leaflet if available from your pharmacist before you start taking cilostazol and each time you get a refillIf you have any questionsask your doctor or pharmacist.

Improvement in symptoms may occur as soon as 2 weeksbut could take up to 12 weeks.

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