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DVisual field defectsPericentral or paracentral scotomacentral scotoma with decreased visual acuityrarely field constrictionabnormal color vision.
Retinopathy appears to be dose related and has occurred within several monthsrarelyto several years of daily therapya small number of cases have been reported several years after antimalarial drug therapy was discontinuedIt has not been noted during prolonged use of weekly doses of the 4aminoquinoline compounds for suppression of malaria.
All patients on long-term therapy with this preparation should be questioned and examined periodicallyincluding the testing of knee and ankle reflexesto detect any evidence of muscular weaknessIf weakness occursdiscontinue the drug.
PLAQUENIL is not effective against chloroquine-resistant strains of Pfalciparum.
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