Rheumatoid arthritis the usual adult dose of methotrexate is 7.

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When used to treat tumorsmethotrexate sometimes causes side effects due to the rapid destruction of cancer cellstumor lysis syndromeTo lower your riskdrink plenty of fluids unless your doctor directs you otherwiseAlsoyour doctor may prescribe an additional medicationTell your doctor right away if you have symptoms such as irregular heartbeatlow back/side painsigns of kidney problemssuch as pink/bloody urinechange in the amount of urinepainful urinationor muscle spasms/weakness.

Do not increase your dose or use this drug more often or for longer than prescribedYour condition will not improve any fasterand your risk of side effects will increase.

Nausea or vomiting stomach pain or upset diarrhea hair loss tiredness dizziness chills headache sores in your lungs mouth sores painful skin sores bronchitis fever bruising more easily increased risk of infection sun sensitivity rash stuffy or runny nose and sore throat abnormal results on liver function testsmay indicate liver damagelow blood cell levels.

Do not take these drugs with methotrexateWhen used with methotrexatethese drugs can cause dangerous effects in your bodyExamples of these drugs include:

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50 mg m im; measure serum hcg levels on days 4 and 7; may repeat dose on day 7 if necessary if hcg levels decrease less than 15 between days 4 and 7, administer methotrexate 50 mg m im; ifhcg 15 or more between days 4 and 7, discontinue treatment and measure hcg weekly until reaching non-pregnant levels.

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Methotrexate self-injectable solution may be used as part of a combination therapyThat means you may need to take it with other drugs.

Unfortunatelydepleting the body of folate can affect healthy cellstooespecially those in the gastrointestinalGItractmouthhair follicles and liversays Prabha RanganathanMDan associate professor of medicine in the division of rheumatology at Washington University School of Medicine.

Maintenanceduring remission15 mg/m2 IM or orally twice a weekAlternate remission dosing2.5 mg/kg IV every 14 days.

If you are a manuse a condom to keep from causing a pregnancy while you are using methotrexateContinue using condoms for at least 3 months after your last dose.

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A few stories from people with ulcerative colitis who have used methotrexate who submitted their experiences to the site previously .

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Malignant lymphoma in Stage III0.625 to 2.5 mg/kg orally daily as a part of combination chemotherapy.

Do not increase your dose or use this drug more often or for longer than prescribedYour condition will not improve any fasterand your risk of side effects will increase.

This drug may make you dizzy or drowsyAlcohol or marijuana can make you more dizzy or drowsyDo not driveuse machineryor do anything that needs alertness until you can do it safelyAvoid alcoholic beveragesTalk to your doctor if you are using marijuana.

Before using this medicationtell your doctor or pharmacist your medical historyespecially ofliver diseasekidney diseaselung diseasesuch as pulmonary fibrosisalcohol usesuppressed immune systemblood cell/bone marrow disordersstomach/intestinal diseasessuch as peptic ulcerulcerative colitisany active infectionincluding chickenpox or recent exposure to itfolic acid deficiency.

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